Kalopanaxsaponin B
Kalopanaxsaponin B
CAS: 14216-03-6
Molecular Formula: C59H96O26
Kalopanaxsaponin B - Names and Identifiers
| Name | Kalopanaxsaponin B |
| Synonyms | HEDERACOSIDE C Hederacoside C Kalopanaxsaponin B kalopanax saponin B KIZUTA SAPONIN K(12 HEDERACOSIDE C WITH HPLC Hederacoside c, froM Hedera nepalensis Olean-12-en-28-oic acid, 3-[[2-O-(6-deoxy-α-l-mannopyranosyl)-α-l-arabinopyranosyl]oxy]-23-hydroxy-, O-6-deoxy-α-l-mannopyranosyl-(1→4)-O-β-d-glucopyranosyl-(1→6)-β-d-glucopyranosyl ester, (3β,4α)- |
| CAS | 14216-03-6 |
| EINECS | 238-072-2 |
| InChI | InChI=1/C59H96O26/c1-24-34(63)38(67)42(71)49(78-24)83-46-29(20-60)80-48(45(74)41(46)70)77-22-30-37(66)40(69)44(73)51(81-30)85-53(75)59-17-15-54(3,4)19-27(59)26-9-10-32-55(5)13-12-33(56(6,23-61)31(55)11-14-58(32,8)57(26,7)16-18-59)82-52-47(36(65)28(62)21-76-52)84-50-43(72)39(68)35(64)25(2)79-50/h9,24-25,27-52,60-74H,10-23H2,1-8H3/t24-,25-,27?,28-,29+,30+,31?,32+,33-,34-,35-,36-,37+,38+,39+,40-,41+,42+,43+,44+,45+,46+,47+,48+,49-,50-,51-,52-,55-,56-,57+,58+,59-/m0/s1 |
| InChIKey | RYHDIBJJJRNDSX-MCGLQMIESA-N |
Kalopanaxsaponin B - Physico-chemical Properties
| Molecular Formula | C59H96O26 |
| Molar Mass | 1221.38 |
| Density | 1.48±0.1 g/cm3(Predicted) |
| Melting Point | 222°C (dec.)(lit.) |
| Specific Rotation(α) | (c, 2.76 in MeOH)-18 |
| Solubility | Soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. |
| Appearance | White crystal |
| Color | White to Pale Beige |
| BRN | 4229541 |
| pKa | 12.50±0.70(Predicted) |
| Storage Condition | Inert atmosphere,2-8°C |
| Stability | Hygroscopic |
| Sensitive | Easily absorbing moisture |
| Refractive Index | 1.637 |
| MDL | MFCD00198062 |
| Physical and Chemical Properties | From the Ranunculaceae plant Pulsatilla Pulsatilla chinensis (Bunge) Regel. |
Kalopanaxsaponin B - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | S22 - Do not breathe dust. S24/25 - Avoid contact with skin and eyes. |
| UN IDs | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| FLUKA BRAND F CODES | 10-23 |
| HS Code | 29389090 |
Kalopanaxsaponin B - Reference
| Reference Show more | 1. Jin, Miao-Miao, et al. "Discrimination and chemical phylogenetic study of four Pulsatilla herbs using UPLC–ESI–MS/MS combined with hierarchical cluster analysis." Journal of chromatographic science 56.3 (2018): 216-224.https://doi.org/10.1093/chromsci/bmx1 2. [IF=3.645] Miao-miao Jin et al."Simultaneous determination of 12 active components in the roots of Pulsatilla chinensis using tissue-smashing extraction with liquid chromatography and mass spectrometry."J Sep Sci. 2017 Mar;40(6):1283-1292 3. [IF=1.618] Jin Miao-Miao et al."Discrimination and Chemical Phylogenetic Study of Four Pulsatilla Herbs Using UPLC–ESI–MS/MS Combined with Hierarchical Cluster Analysis."J Chromatogr Sci. 2018 Mar;56(3):216-224 |
Kalopanaxsaponin B - Reference Information
| overview | ivy glycoside c is also called ivy saponin c. Ivy, also known as ivy, ivy, diamond centipede (Leshan area, Sichuan), soil ivy, etc., ivy plants of the genus Araceae. It has the effects of dispelling wind, removing dampness, callifying liver and detoxifying. It can effectively resist carcinogens in nicotine and absorb toxic substances such as formaldehyde. Ivy glycoside C in its leaf extract has excellent expectorant and antispasmodic effects. It has been used in clinical treatment of respiratory diseases. It has become a natural active ingredient that people pay attention to and has great medicinal value and market prospects. |
| basic overview | plant source: ivy properties: this product is white crystalline powder. Ivy glycoside C, evergreen climbing vine. The stems and branches have aerial roots, and the young branches are scaly pilose. Leaves alternate, 2-lobed, leathery, with long stalks; leaves on vegetative branches are triangular-ovate or nearly halberd-shaped, 5 ~ 10cm long, 3 ~ 8cm wide, apex acuminate, base cuneate, entire or 3-lobed; leaves on flower branches are elliptic-ovate or elliptic-lanceolate surface, 5 ~ 12cm long, 1 ~ 8cm wide, apex long-pointed, base cuneate, entire. Umbels are solitary or 2~7 terminal; flowers are small, yellow-white or green-white, with 5 flowers; ovary inferior, styles connate into columnar. Fruit rounded, berrylike, yellow or red. The flowering period is from May to August and the fruiting period is from September to November. Attached to the trunk of trees in broad-leaved forests or on the damp rock walls of valleys. Produced in Shaanxi, Gansu and the south of the Yellow River Basin to South China and Southwest China. |
| use | ivy glycoside c is used for content determination/identification/pharmacological experiment, etc. used for content determination/identification/pharmacological experiment, etc. Pharmacological effect: It has certain anti-tumor activity. |
| solubility | soluble in methanol, acetonitrile, ethanol and other solvents, insoluble in petroleum ether. |
| pharmacological effect | has certain anti-tumor effect, and is used for content determination, identification, pharmacological experiment, activity screening, etc. /td>/tr> td style = "min-width:90px"> precautions for operation steps/td> td> high purity, accurate detection/identification and strong stability. in order to prevent the product content from decreasing, it is not suitable to be exposed to the air. it should be packed with moisture-proof, light-proof and anti-oxidation. the preservation should be based on the principle of improving the stability of the substance, store as much as possible under dry and low temperature conditions (liquid or deliquescent substance is packed in a melt-sealed glass ampoule). |
| preparation | 500g of dry ivy stems and leaves are taken, crushed, heated and refluxed twice with 4000mL and 2000mL of 30% ethanol at 80 ℃ for 3 hours and 2 hours respectively. Merge the two extracts and recover the solvent under reduced pressure to obtain crude ivy extract. The crude extract of ivy is put into an ultrasonic generator and dissolved in 150mL of water, and the aqueous solution is extracted with equal volume of ether, ethyl acetate and n-butanol for 3 times respectively. Three times of n-butanol extract were combined, concentrated under reduced pressure to near-dry, and then dissolved with 80mL of 95% ethanol. Under stirring, ethyl acetate is gradually added to the 95% ethanol solution until precipitation is no longer generated, and the sediment is filtered and collected after standing for 2 hours. The precipitate was dissolved with a small amount of methanol, and column chromatography elution was carried out with silica gel as the stationary phase and a mixture of chloroform: methanol equal to 65: 35 as the mobile phase. The eluent was collected, the collected eluent containing ivy glycoside C was concentrated, freeze-dried to obtain ivy glycoside C1.0759g, and the content of ivy glycoside C was 98.2% by high performance liquid chromatography. |
| References | http://www.chemmade.com/assistant/chemdic/casDetail-14216-03-6.html http://www.hbzhan.com/Product/detail/15328907.html |
| chemical properties | from the Ranunculaceae plant Pulsatilla Pulsatilla chinensis (Bunge) Regel. |
Last Update：2024-04-09 21:54:55
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